TINAP is a non-profit association seeking support from foundations, research institutions, and individuals committed to advancing a new systems-level understanding of cancer.
Dear Potential Supporter,
For decades, the Somatic Mutation Theory (SMT) has dominated cancer research. Despite enormous investment, the rate of genuine therapeutic breakthrough β particularly for solid tumours β has not matched expectations.
TINAP has developed the RCA (Repair and Capacity Adaptation) framework, which proposes that cancer is a systemic failure of differentiation control rather than primarily a mutation-driven disease. This reframing is consistent with decades of evidence from APL, Bissell's ECM work, and the progenitor biology literature.
"We have not wasted time finding the components, but we may have failed by believing we could control them like cogwheels. The reality is that we are trying to steer a process that is wiser than ourselves."
We seek support to:
This is not an alternative to existing cancer research β it is an attempt to identify the missing regulatory layer that connects existing evidence into a coherent system.
With kind regards,
The TINAP Board
RCA proposes a new systems layer above TME and TOFT β connecting APL, Bissell, and progenitor biology into a unified falsifiable framework.
Papers published on bioRxiv and Zenodo, available for peer review and collaboration.
Bringing together biology, medicine, systems theory, and psychobiology to address cancer as a regulatory failure.
Donations and grants of any scale help drive the experimental validation program forward.
Bank account: Contact us for bank details | CVR: 42144738
Help us reach conceptual leaders and potential experimental partners by sharing our publications.
Affiliated with a research institution or lab? We are seeking partners for the validation phase.
We welcome conversations with foundations, institutions, and individual supporters.